Anti-Inflammatory Indole Alkaloids from the Stems of Kopsia officinalis
Xie Tian-Zhen1,2; Zhao Yun-Li2; Ma Wei-Guang3; Wang Yi-Fen2; Yu Hao-Fei1; Wang Bei2; Wei Xin2; Huang Zhi-Pu3; Zhu Pei-Feng2; Liu Ya-Ping2; Luo Xiao-Dong1,2
Corresponding AuthorLiu Ya-Ping( ; Luo Xiao-Dong(
AbstractSeven new monoterpenoid indole alkaloids, kopsiofficines A similar to G, together with twenty known alkaloids, were isolated from the stems of Kopsia officinalis. Their structures were elucidated on the basis of extensive spectroscopic methods. The anti-inflammatory activities of all alkaloids were evaluated on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells by the inhibiting the production of IL-1 beta, PGE2 and TNF-alpha. Among them, kopsiofficines A (1), kopsiofficines B (2), kopsiofficines D (4), kopsiofficines F (6), kopsiofficines G (7), 12-methoxykopsine (11), kopsinoline (15), (-)-N-methoxycarbonyl-11,12-methylenedioxykopsinaline (16), kopsinine (18) and kopsinic acid (20) exhibited significant anti-inflammatory activity, which were comparable to that of dexamethasone. The results supposed that the acetonyl group at C-5 of monoterpenoid indole alkaloids play an important role in their anti-inflammatory activity.
KeywordKopsia officinalis kopsiofficines A similar to G anti-inflammatory monoterpenoid indole alkaloids
Indexed BySCI ; SCI
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000531082100012
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLiu Ya-Ping; Luo Xiao-Dong
Affiliation1.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Yunnan Univ Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Xie Tian-Zhen,Zhao Yun-Li,Ma Wei-Guang,et al. Anti-Inflammatory Indole Alkaloids from the Stems of Kopsia officinalis[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2020,40(3):679-687.
APA Xie Tian-Zhen.,Zhao Yun-Li.,Ma Wei-Guang.,Wang Yi-Fen.,Yu Hao-Fei.,...&Luo Xiao-Dong.(2020).Anti-Inflammatory Indole Alkaloids from the Stems of Kopsia officinalis.CHINESE JOURNAL OF ORGANIC CHEMISTRY,40(3),679-687.
MLA Xie Tian-Zhen,et al."Anti-Inflammatory Indole Alkaloids from the Stems of Kopsia officinalis".CHINESE JOURNAL OF ORGANIC CHEMISTRY 40.3(2020):679-687.
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