Unusual glycosidic labdane diterpenoids with cytotoxicity from the root of Phlomoides betonicoides
Geng, Hao1,2,3; Liu, Yan-Chun1,2; Li, De-Sen1,2,3; Xiao, Chao-Jiang1,2; Liu, Yan1,2; Li, Xiao-Nian1,2; Li, Sheng-Hong1,2
Corresponding AuthorLi, Sheng-Hong(shli@mail.kib.ac.cn)
2020-05-01
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume173Pages:8
AbstractChemical investigation on the root of Phlomoides betonicoides led to the isolation of six undescribed diterpenoid glycosides, phlomoidesides A-F, along with two known ones using various chromatographic techniques. The structures of these compounds were determined by extensive spectroscopic analyses (including 1D, 2D-NMR and HRMS), single crystal X-ray diffraction, and calculated C-13 NMR. The glycoside modifications of phlomoidesides A-F are rare in natural products, and a plausible biosynthetic pathway for these unusual glycosides was proposed. Phlomoidesides A, D, F, and phlomisosides V,III were cytotoxic against three human tumor cell lines, NCI-H1975, HepG2 and MCF-7, with IC50 values ranging from 7.5 to 75.7 mu M. Phlomoideside B only showed weak cytotoxicity against NCI-H1975, with IC50 of 53.0- mu M.
KeywordPhlomoides betonicoides Lamiaceae Diterpenoid glycosides Phlomoidesides A-F Cytotoxic activity
DOI10.1016/j.phytochem.2020.112325
Indexed BySCI ; SCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000528188900019
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71626
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLi, Sheng-Hong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Geng, Hao,Liu, Yan-Chun,Li, De-Sen,et al. Unusual glycosidic labdane diterpenoids with cytotoxicity from the root of Phlomoides betonicoides[J]. PHYTOCHEMISTRY,2020,173:8.
APA Geng, Hao.,Liu, Yan-Chun.,Li, De-Sen.,Xiao, Chao-Jiang.,Liu, Yan.,...&Li, Sheng-Hong.(2020).Unusual glycosidic labdane diterpenoids with cytotoxicity from the root of Phlomoides betonicoides.PHYTOCHEMISTRY,173,8.
MLA Geng, Hao,et al."Unusual glycosidic labdane diterpenoids with cytotoxicity from the root of Phlomoides betonicoides".PHYTOCHEMISTRY 173(2020):8.
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