One-pot synthesis and biological and catalytic applications of organometallic complexes involving oxazolines and (R)/(S)-a-phenylethylamine
Luo, Mei1; Li, Hong Mei2
Corresponding AuthorLuo, Mei(luomei@pku.edu.cn)
2020-04-01
Source PublicationJOURNAL OF THE IRANIAN CHEMICAL SOCIETY
ISSN1735-207X
Volume17Issue:4Pages:963-971
AbstractThe crystal structures of zinc complexes 1 and 3 were determined following synthesis via a one-pot method involving the reaction of 2-hydro-6-methyl-nicotinonitrile and 2-cyanopyridine with different l-amino alcohols mediated by 120-130 mol% ZnCl2. Copper complex 4 and cobalt complex 5 were prepared by reacting (R)/(S)-a-phenylethylamine with dimethyl dichloride silane in the presence of 52 mol% CuCl2 or 50 mol% CoCl2 as the third components. Crystalline compounds 1-5 were all characterized by elemental analysis, IR and NMR spectroscopies, and X-ray diffraction. Then, complexes 1 and 3-5 were evaluated for cytotoxicity against the human tumor cell line SMMC-7721 and were also used as catalysts in the nucleophilic addition reaction of trimethylsilonitrile with diphenylketimine. Both complexes exhibited anticancer activity against the human tumor cell line SMMC-7721 and showed enhanced catalytic effects.
KeywordOrganometallic complexes One-pot method Nitriles l-amino alcohols (R) (S)-a-phenylethylamine Dimethyl dichloride silane Cytotoxicity Nucleophilic addition reaction of trimethylsilonitrile with diphenylketimine
DOI10.1007/s13738-019-01830-z
Indexed BySCI ; SCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000519963900021
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71357
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLuo, Mei
Affiliation1.Hefei Univ Technol, Coll Chem & Chem Engn, Hefei 230009, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resource West Chi, Kunming 650201, Yunnan, Peoples R China
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Luo, Mei,Li, Hong Mei. One-pot synthesis and biological and catalytic applications of organometallic complexes involving oxazolines and (R)/(S)-a-phenylethylamine[J]. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY,2020,17(4):963-971.
APA Luo, Mei,&Li, Hong Mei.(2020).One-pot synthesis and biological and catalytic applications of organometallic complexes involving oxazolines and (R)/(S)-a-phenylethylamine.JOURNAL OF THE IRANIAN CHEMICAL SOCIETY,17(4),963-971.
MLA Luo, Mei,et al."One-pot synthesis and biological and catalytic applications of organometallic complexes involving oxazolines and (R)/(S)-a-phenylethylamine".JOURNAL OF THE IRANIAN CHEMICAL SOCIETY 17.4(2020):963-971.
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