Chemical Constituents from Turnip and Their Effects on alpha-Glucosidase
Paul, Swastika1,3; Zhang, Xuemei1; Yang, Yongping2; Geng, Changan1
Corresponding AuthorGeng, Changan(gengchangan@mail.kib.ac.cn)
2020
Source PublicationPHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY
ISSN1851-5657
Volume89Issue:1Pages:131-136
AbstractBrassica rapa var. rapa (turnip) is an important crop in Qinghai-Tibet Plateau (QTP) with anti-hypoxic effect. Turnip is rich in glucosinolates, isothiocyanates and phenolic compounds with diverse biological activities, involving anti-oxidant, anti-tumor, anti-diabetic, anti-inflammatory, anti-microbial, hypolipidemic, cardioprotective, hepatoprotective, nephroprotective and analgesic properties. In this study, the ethyl acetate (EtOAc) and butanol parts of Brassica rapa were first revealed with inhibitory effects on alpha-glucosidase, whereas the water part was inactive. Subsequent bioassay-guided isolation on the EtOAc and butanol parts yielded 12 compounds, involving three indole derivatives, indole-3-acetonitrile (1) 4-methoxyindole-3-acetonitrile (2) and indole-3-aldehyde (3) two flavonoids, liquiritin (4) and licochalcone A (5) two phenylpropanoids, sinapic acid (6) and caffeic acid (7) two phenylethanol glycosides, 2-phenylethyl beta-glucopyranoside (8) and salidroside (9) and three other compounds, syringic acid (10) adenosine (11) and (3 beta, 20E)-ergosta-5, 20 (22)-dien-3-ol (12) Licochalcone A (5) and caffeic acid (7) showed alpha-glucosidase inhibitory activity with IC50 values of 62.4 +/- 8.0 mu M and 162.6 +/- 3.2 mu M, comparable to the positive control, acarbose (IC50 = 142 +/- 0.02 mu M). Docking study suggested that licochalcone A (5) could well align in the active site of alpha-glucosidase (docking score = -52.88) by forming hydrogen bonds (Gln1372, Asp1420, Gln1372, Arg1510), hydrophobic effects (Tyr1251, Tyr1251, Trp1355, Phe1560, Ile1587, Trp1355, Phe1559, Phe1559) and pi-pi stacking interaction (Trp1355). This study provides valuable information for turnip as a new resource in searching anti-diabetic candidates.
KeywordBrassica rapa turnip alpha-glucosidase licochalcone A docking study
DOI10.32604/phyton.2020.08328
Indexed BySCI ; SCI
Language英语
WOS Research AreaPlant Sciences
WOS SubjectPlant Sciences
WOS IDWOS:000519775600013
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71353
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorGeng, Changan
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Inst Tibetan Plateau Res Kunming, Kunming Inst Bot, Key Lab Biodivers & Biogeog, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Paul, Swastika,Zhang, Xuemei,Yang, Yongping,et al. Chemical Constituents from Turnip and Their Effects on alpha-Glucosidase[J]. PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY,2020,89(1):131-136.
APA Paul, Swastika,Zhang, Xuemei,Yang, Yongping,&Geng, Changan.(2020).Chemical Constituents from Turnip and Their Effects on alpha-Glucosidase.PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY,89(1),131-136.
MLA Paul, Swastika,et al."Chemical Constituents from Turnip and Their Effects on alpha-Glucosidase".PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY 89.1(2020):131-136.
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