Two anti-inflammatory chlorinated azaphilones from Chaetomium globosum TW1-1 cultured with 1-methyl-L-tryptophan and structure revision of chaephilone C
Gao, Weixi1,2; Chai, Chenwei1; Li, Xiao-Nian3; Sun, Weiguang1; Li, Fengli1; Chen, Chunmei1; Wang, Jianping1; Zhu, Hucheng1; Wang, Yanyan4,5; Hu, Zhengxi1; Zhang, Yonghui1
Corresponding AuthorWang, Yanyan(wangyy1001@163.com) ; Hu, Zhengxi(hzx616@126.com) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn)
2020-02-20
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume61Issue:8Pages:4
AbstractBy feeding 1-methyl-L-tryptophan (1-MT) into the inactivated rice cultures of an arthropod-derived fungus Chaetomium globosum TW1-1, two new chlorinated azaphilones (1 and 2) were isolated and identified. Their structures incorporating absolute configurations were determined by comprehensive spectroscopic analyses and single-crystal X-ray diffraction. Remarkably, chaephilone C, which was reported to possess an unprecedented 6-6-5-6-fused ring system with a chlorine substitution, was structurally revised to 1. Chaephilones C (1) and D (2) showed moderate anti-inflammatory activity against the NO production with IC50 values of 15.12 +/- 1.48 and 20.65 +/- 0.95 mu M, respectively. (C) 2019 Elsevier Ltd. All rights reserved.
KeywordChaetomium globosum TW1-1 Chlorinated azaphilones Single-crystal X-ray diffraction Structure revision
DOI10.1016/j.tetlet.2019.151516
Indexed BySCI ; SCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000514753000006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71301
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorWang, Yanyan; Hu, Zhengxi; Zhang, Yonghui
Affiliation1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
2.Wuhan Univ, Dept Pharm, Renmin Hosp, Wuhan 430060, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
4.Three Gorges Univ, Coll Clin Med Sci China 1, Yichang 443003, Peoples R China
5.Yichang Cent Peoples Hosp, Yichang 443003, Peoples R China
Recommended Citation
GB/T 7714
Gao, Weixi,Chai, Chenwei,Li, Xiao-Nian,et al. Two anti-inflammatory chlorinated azaphilones from Chaetomium globosum TW1-1 cultured with 1-methyl-L-tryptophan and structure revision of chaephilone C[J]. TETRAHEDRON LETTERS,2020,61(8):4.
APA Gao, Weixi.,Chai, Chenwei.,Li, Xiao-Nian.,Sun, Weiguang.,Li, Fengli.,...&Zhang, Yonghui.(2020).Two anti-inflammatory chlorinated azaphilones from Chaetomium globosum TW1-1 cultured with 1-methyl-L-tryptophan and structure revision of chaephilone C.TETRAHEDRON LETTERS,61(8),4.
MLA Gao, Weixi,et al."Two anti-inflammatory chlorinated azaphilones from Chaetomium globosum TW1-1 cultured with 1-methyl-L-tryptophan and structure revision of chaephilone C".TETRAHEDRON LETTERS 61.8(2020):4.
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