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Microbial transformation of diosgenin to diosgenone by Wickerhamomyces anomalus JQ-1 obtained from Naxi traditional Jiu Qu
Li, Liangqun1; Zhao, Yanqiang2; Lang, Bayi3; Xie, Yuying1; Meng, Manfred Shaowu4; He, Yun5; Yang, Lixin1,3; Liu, Aizhong1,3,6
Corresponding AuthorYang, Lixin(rattan@mail.kib.ac.cn) ; Liu, Aizhong(liuaizhong@mail.kib.ac.cn)
2020
Source PublicationBIOORGANIC CHEMISTRY
ISSN0045-2068
Volume95Pages:6
AbstractDiosgenone [(20S,22R,25R)-spirost-4-en-3-one, C27H40O3] has been considered as a potential therapeutic alternative remedy for malaria. An efficient and economical approach of microbial transformation with diosgenin to diosgenone by the yeast strain Wickerhamomyces anomalus JQ-1 from Naxi traditional Jiu Qu was developed in this study. Chromatographic analysis confirmed that 85% of 0.1 mM diosgenin was transformed to diosgenone within 72 h. This research demonstrates that diosgenin could be converted to diosgenone through two-step pathway including 3 beta-hydroxyl oxidation and double bond isomerization rather than through one-step pathway, which prompted a further inference that the oxidation activity in W. anomalus JQ-1 has the same function with the Oppenauer-type oxidation which can convert diosgenin into diosgenone. Gaining specific functional strains from traditional fermented products will be a potential direction and ethnobotanical researches could provide helps with discovery and utilization of microbial resources.
KeywordDiosgenone Oppenauer oxidation Wickerhamomyces anomalus Biotranformation
DOI10.1016/j.bioorg.2019.103508
Indexed BySCI ; SCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Organic
WOS IDWOS:000512762900029
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71298
Collection资源植物与生物技术所级重点实验室
Corresponding AuthorYang, Lixin; Liu, Aizhong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Yunnan Key Lab Wild Plant Resources, Kunming 650201, Yunnan, Peoples R China
2.Coll Forestry & Vocat Technol Yunnan, Kunming 650224, Yunnan, Peoples R China
3.Ctr Biodivers & Indigenous Knowledge, Kunming 650034, Yunnan, Peoples R China
4.Duke Univ, Duke Global Hlth Inst, Durham, NC 27708 USA
5.Lijiang Yunxin Green Biol Dev Co Ltd, Lijiang 674119, Yunnan, Peoples R China
6.Southwest Forestry Univ, Key Lab Forest Resources Conservat & Utilizat Sou, Minist Educ, Kunming 650224, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, Liangqun,Zhao, Yanqiang,Lang, Bayi,et al. Microbial transformation of diosgenin to diosgenone by Wickerhamomyces anomalus JQ-1 obtained from Naxi traditional Jiu Qu[J]. BIOORGANIC CHEMISTRY,2020,95:6.
APA Li, Liangqun.,Zhao, Yanqiang.,Lang, Bayi.,Xie, Yuying.,Meng, Manfred Shaowu.,...&Liu, Aizhong.(2020).Microbial transformation of diosgenin to diosgenone by Wickerhamomyces anomalus JQ-1 obtained from Naxi traditional Jiu Qu.BIOORGANIC CHEMISTRY,95,6.
MLA Li, Liangqun,et al."Microbial transformation of diosgenin to diosgenone by Wickerhamomyces anomalus JQ-1 obtained from Naxi traditional Jiu Qu".BIOORGANIC CHEMISTRY 95(2020):6.
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