Spirostanol and sesquiterpenoid glycosides from the rhizomes of Trillium tschonoskii
Li, Dan1,2,3; Yan, Huan1,2; Wang, Jie1,2,3; Yu, Qian4; Ni, Wei1,2; An, Lin-Kun4; Qin, Xu-Jie1,2; Liu, Hai-Yang1,2
Corresponding AuthorQin, Xu-Jie(qinxujie@mail.kib.ac.cn) ; Liu, Hai-Yang(haiyangliu@mail.kib.ac.cn)
2020-03-01
Source PublicationSTEROIDS
ISSN0039-128X
Volume155Pages:7
AbstractThree new spirostanol glycosides, trilliumosides K-M (1-3), one new sesquiterpenoid glycoside, tritschsesuquiside A (4), along with three known analogues (5-7) were obtained from the rhizomes of Trilliwn tschonoskii. The structures of new glycosides were elucidated by spectroscopic analyses (HRMS and NMR) and chemical methods. Glycosides 5-7 displayed cytotoxicities against five human cancer cell lines with IC50 values ranging from 10.5 +/- 1.0 to 1.0 +/- 0.2 mu M, with 7 being the most cytotoxic compound with IC50 values of 1.0 +/- 0.2, 2.2 +/- 1.2, and 3.4 +/- 0.4 mu M against Huh7, CCRF-CEM, and HeLa cell lines, respectively. The flow cytometric results revealed that both 5 and 6 could induce apoptosis of HCT116 and Huh7 cells.
KeywordTrillium tschonoskii Spirostanol glycosides Sesquiterpenoid glycoside Cytotoxicity Apoptosis
DOI10.1016/j.steroids.2019.108569
Indexed BySCI ; SCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS IDWOS:000517349300006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71292
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorQin, Xu-Jie; Liu, Hai-Yang
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem & Chem Biol, Guangzhou 510006, Peoples R China
Recommended Citation
GB/T 7714
Li, Dan,Yan, Huan,Wang, Jie,et al. Spirostanol and sesquiterpenoid glycosides from the rhizomes of Trillium tschonoskii[J]. STEROIDS,2020,155:7.
APA Li, Dan.,Yan, Huan.,Wang, Jie.,Yu, Qian.,Ni, Wei.,...&Liu, Hai-Yang.(2020).Spirostanol and sesquiterpenoid glycosides from the rhizomes of Trillium tschonoskii.STEROIDS,155,7.
MLA Li, Dan,et al."Spirostanol and sesquiterpenoid glycosides from the rhizomes of Trillium tschonoskii".STEROIDS 155(2020):7.
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