Antitumor pyridine alkaloids hybrid with diverse units from Alangium chinense
Wei, Xin1,3; Yang, Jing1; Dai, Zhi2; Yu, Hao-Fei1; Ding, Cai-Feng1; Khan, Afsar4; Zhao, Yun-Li1; Liu, Ya-Ping1; Luo, Xiao-Dong1,2
Corresponding AuthorLuo, Xiao-Dong(xdluo@mail.kib.ac.cn)
2020-02-13
Source PublicationTETRAHEDRON LETTERS
ISSN0040-4039
Volume61Issue:7Pages:5
AbstractAlangiumines A-C (1-3), three novel additive pyridine alkaloids representing the unprecedented santanolide-anabasine, benzcyclohexanone-anabasine, and cyclopentenone-anabasine skeletons, were isolated from Alangium chinense. Their structures with absolute configurations were elucidated by spectroscopic techniques and electronic circular dichroism (ECD). Moreover, compound I exhibited selective antitumor in vitro activity against glioma stem cells (GSCs). This finding might provide new type of lead for the selective killing of human glioma stem cells. (C) 2019 Elsevier Ltd. All rights reserved.
KeywordAlangium chinense Additive pyridines Selective antitumor activity Glioma stem cells
DOI10.1016/j.tetlet.2019.151502
Indexed BySCI ; SCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000514248200020
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71211
Collection植物化学与西部植物资源持续利用国家重点实验室
Corresponding AuthorLuo, Xiao-Dong
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ & Yunnan Prov, Kunming 650091, Yunnan, Peoples R China
3.Guizhou Univ Tradit Chinese Med, Guiyang 550025, Peoples R China
4.COMSATS Univ Islamabad, Dept Chem, Abbottabad Campus, Abbottabad 22060, Pakistan
Recommended Citation
GB/T 7714
Wei, Xin,Yang, Jing,Dai, Zhi,et al. Antitumor pyridine alkaloids hybrid with diverse units from Alangium chinense[J]. TETRAHEDRON LETTERS,2020,61(7):5.
APA Wei, Xin.,Yang, Jing.,Dai, Zhi.,Yu, Hao-Fei.,Ding, Cai-Feng.,...&Luo, Xiao-Dong.(2020).Antitumor pyridine alkaloids hybrid with diverse units from Alangium chinense.TETRAHEDRON LETTERS,61(7),5.
MLA Wei, Xin,et al."Antitumor pyridine alkaloids hybrid with diverse units from Alangium chinense".TETRAHEDRON LETTERS 61.7(2020):5.
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