Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity

doi:10.1016/j.phytochem.2019.112127

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	Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity
	Wang,Zengyuan; Jiang,Mengjun; Khan,Afsar; Cai,Shengbao; Li,Xiaonian; Liu,Junqiu; Kai,Guoyin; Zhao,Tianrui; Cheng,Guiguang; Cao,Jianxin
	2019
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	168 页码:UNSP 112127
摘要	Five undescribed C-21 pregnane glycosides, epigycosides D - H, together with four known analogues, two lignans, and a flavonoid have been isolated from the stems of Epigynum cochinchinensis. The structures of pregnane glycosides were elucidated using spectroscopic techniques and acid hydrolysis. The in vitro immunological activities were assessed against Con A-stimulated proliferation of mice splenocytes. The C-21 pregnane glycosides showed immunosuppressive activity in a concentration-dependent manner. Moreover, epigycoside E exhibited a potent immunosuppressive effect, and the IC50 value on Con A-stimulated mice splenocytes was 22.1 +/- 6.4 mu M. Epigycoside E also caused G(0)/G(1) arrest, and inhibited TNF-alpha and IL-2 production.
DOI	10.1016/j.phytochem.2019.112127
收录类别	SCI
WOS记录号	WOS:000496894000010
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/71103
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang,Zengyuan,Jiang,Mengjun,Khan,Afsar,et al. Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity[J]. PHYTOCHEMISTRY,2019,168:UNSP 112127.
APA	Wang,Zengyuan.,Jiang,Mengjun.,Khan,Afsar.,Cai,Shengbao.,Li,Xiaonian.,...&Cao,Jianxin.(2019).Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity.PHYTOCHEMISTRY,168,UNSP 112127.
MLA	Wang,Zengyuan,et al."Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity".PHYTOCHEMISTRY 168(2019):UNSP 112127.

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