Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity

doi:10.1016/j.phytochem.2019.112127

KIB OpenIR

	Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity
	Wang,Zengyuan; Jiang,Mengjun; Khan,Afsar; Cai,Shengbao; Li,Xiaonian; Liu,Junqiu; Kai,Guoyin; Zhao,Tianrui; Cheng,Guiguang; Cao,Jianxin
	2019
Source Publication	PHYTOCHEMISTRY
ISSN	0031-9422
Volume	168 Pages:UNSP 112127
Abstract	Five undescribed C-21 pregnane glycosides, epigycosides D - H, together with four known analogues, two lignans, and a flavonoid have been isolated from the stems of Epigynum cochinchinensis. The structures of pregnane glycosides were elucidated using spectroscopic techniques and acid hydrolysis. The in vitro immunological activities were assessed against Con A-stimulated proliferation of mice splenocytes. The C-21 pregnane glycosides showed immunosuppressive activity in a concentration-dependent manner. Moreover, epigycoside E exhibited a potent immunosuppressive effect, and the IC50 value on Con A-stimulated mice splenocytes was 22.1 +/- 6.4 mu M. Epigycoside E also caused G(0)/G(1) arrest, and inhibited TNF-alpha and IL-2 production.
DOI	10.1016/j.phytochem.2019.112127
Indexed By	SCI
WOS ID	WOS:000496894000010
Citation statistics	Cited Times:14[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.kib.ac.cn/handle/151853/71103
Collection	中国科学院昆明植物研究所
Recommended Citation GB/T 7714	Wang,Zengyuan,Jiang,Mengjun,Khan,Afsar,et al. Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity[J]. PHYTOCHEMISTRY,2019,168:UNSP 112127.
APA	Wang,Zengyuan.,Jiang,Mengjun.,Khan,Afsar.,Cai,Shengbao.,Li,Xiaonian.,...&Cao,Jianxin.(2019).Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity.PHYTOCHEMISTRY,168,UNSP 112127.
MLA	Wang,Zengyuan,et al."Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity".PHYTOCHEMISTRY 168(2019):UNSP 112127.

Files in This Item:
File Name/Size	DocType	Version	Access	License
Wang-2019-Epigynumge（1502KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	View Application Full Text

File name:	Wang-2019-Epigynumgenane-type pregnane glycosi.pdf
Format:	Adobe PDF

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院昆明植物研究所知识管理系统