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Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity
Wang,Zengyuan; Jiang,Mengjun; Khan,Afsar; Cai,Shengbao; Li,Xiaonian; Liu,Junqiu; Kai,Guoyin; Zhao,Tianrui; Cheng,Guiguang; Cao,Jianxin
2019
Source PublicationPHYTOCHEMISTRY
ISSN0031-9422
Volume168Pages:UNSP 112127
AbstractFive undescribed C-21 pregnane glycosides, epigycosides D - H, together with four known analogues, two lignans, and a flavonoid have been isolated from the stems of Epigynum cochinchinensis. The structures of pregnane glycosides were elucidated using spectroscopic techniques and acid hydrolysis. The in vitro immunological activities were assessed against Con A-stimulated proliferation of mice splenocytes. The C-21 pregnane glycosides showed immunosuppressive activity in a concentration-dependent manner. Moreover, epigycoside E exhibited a potent immunosuppressive effect, and the IC50 value on Con A-stimulated mice splenocytes was 22.1 +/- 6.4 mu M. Epigycoside E also caused G(0)/G(1) arrest, and inhibited TNF-alpha and IL-2 production.
DOI10.1016/j.phytochem.2019.112127
Indexed BySCI
WOS IDWOS:000496894000010
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/71103
Collection中国科学院昆明植物研究所
Recommended Citation
GB/T 7714
Wang,Zengyuan,Jiang,Mengjun,Khan,Afsar,et al. Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity[J]. PHYTOCHEMISTRY,2019,168:UNSP 112127.
APA Wang,Zengyuan.,Jiang,Mengjun.,Khan,Afsar.,Cai,Shengbao.,Li,Xiaonian.,...&Cao,Jianxin.(2019).Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity.PHYTOCHEMISTRY,168,UNSP 112127.
MLA Wang,Zengyuan,et al."Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity".PHYTOCHEMISTRY 168(2019):UNSP 112127.
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