Asperpyridone A: An Unusual Pyridone Alkaloid Exerts Hypoglycemic Activity through the Insulin Signaling Pathway

doi:10.1021/acs.jnatprod.9b00188

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	Asperpyridone A: An Unusual Pyridone Alkaloid Exerts Hypoglycemic Activity through the Insulin Signaling Pathway
	Qiao,Yuben; Xu,Qianqian; Feng,Wenya; Tao,Li; Li,Xiao-Nian; Liu,Junjun; Zhu,Hucheng; Lu,Yuanyuan; Wang,Jianping; Qi,Changxing; Xue,Yongbo; Zhang,Yonghui
	2019
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	82 期号:10 页码:2925-2930
摘要	A pyridone alkaloid, asperpyridone A (1), which possesses an unusual pyrano[3,2-c]pyridine scaffold, was isolated from solid cultures of the endophytic fungus Aspergillus sp. TJ23. Its structure, including its absolute configuration, was determined using a combination of nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, quantum chemical calculations (electronic circular dichroism), and X-ray crystallography. In vitro bioassays demonstrated that asperpyridone A (1) could function as a potential hypoglycemic agent, which exhibited pronounced glucose uptake effect in liver HepG2 cells, under both normal and insulin-resistant conditions, with higher efficacy than metformin. The underlying mechanism of asperpyridone A was elucidated by analyzing the genes expressed, the Gene Ontology (GO) function enrichment, the protein interaction network, and real-time quantitative reverse transcription polymerase chain reaction, which suggested that asperpyridone A exhibits hypoglycemic activity by activating the insulin signaling pathway. Moreover, on the basis of the hypoglycemic potency, fibroblast growth factor 21 (FGF21) was determined to be a potential target for asperpyridone A.
DOI	10.1021/acs.jnatprod.9b00188
收录类别	SCI
WOS记录号	WOS:000500026300028
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/71084
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Qiao,Yuben,Xu,Qianqian,Feng,Wenya,et al. Asperpyridone A: An Unusual Pyridone Alkaloid Exerts Hypoglycemic Activity through the Insulin Signaling Pathway[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(10):2925-2930.
APA	Qiao,Yuben.,Xu,Qianqian.,Feng,Wenya.,Tao,Li.,Li,Xiao-Nian.,...&Zhang,Yonghui.(2019).Asperpyridone A: An Unusual Pyridone Alkaloid Exerts Hypoglycemic Activity through the Insulin Signaling Pathway.JOURNAL OF NATURAL PRODUCTS,82(10),2925-2930.
MLA	Qiao,Yuben,et al."Asperpyridone A: An Unusual Pyridone Alkaloid Exerts Hypoglycemic Activity through the Insulin Signaling Pathway".JOURNAL OF NATURAL PRODUCTS 82.10(2019):2925-2930.

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