Site-specific peak intensity ratio (SPIR) from 1D H-2/H-1 NMR spectra for rapid distinction between natural and synthetic nicotine and detection of possible adulteration

doi:10.1007/s00216-019-02023-6

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	Site-specific peak intensity ratio (SPIR) from 1D H-2/H-1 NMR spectra for rapid distinction between natural and synthetic nicotine and detection of possible adulteration
	Liu,Bin; Chen,Yanli; Ma,Xiaofang; Hu,Kaifeng
	2019
发表期刊	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN	1618-2642
卷号	411 期号:24 页码:6427-6434
摘要	H-1 and H-2 NMR spectra of 4 natural and synthetic nicotine samples were collected in a non-quantitative way and site-specific H-2/H-1 peak intensity ratio (SPIR) was calculated for 12 distinct sites of nicotine. Experimental results illustrated that the SPIRs at sites of 6, 2 ', and 5 'beta of natural nicotine were significantly different from those of the synthetic nicotine, and could be used for nicotine authentication as the measured SPIRs were indicative of the site-specific natural isotope fractionation. We demonstrated that this method could be applied to detect adulteration of natural nicotine with as low as 20% synthetic nicotine, without the need to measure the site-specific delta D values, which usually required time-consuming quantitative H-2 NMR and additional IRMS for the overall H-2/H-1 isotopic ratio determination. The distinguishable H-2/H-1 SPIRs of nicotine, which can be quickly measured by NMR in non-quantitative way, can serve as an attractive alternative tool for tobacco authentication.
DOI	10.1007/s00216-019-02023-6
收录类别	SCI
WOS记录号	WOS:000483638800020
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/71063
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Liu,Bin,Chen,Yanli,Ma,Xiaofang,et al. Site-specific peak intensity ratio (SPIR) from 1D H-2/H-1 NMR spectra for rapid distinction between natural and synthetic nicotine and detection of possible adulteration[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2019,411(24):6427-6434.
APA	Liu,Bin,Chen,Yanli,Ma,Xiaofang,&Hu,Kaifeng.(2019).Site-specific peak intensity ratio (SPIR) from 1D H-2/H-1 NMR spectra for rapid distinction between natural and synthetic nicotine and detection of possible adulteration.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,411(24),6427-6434.
MLA	Liu,Bin,et al."Site-specific peak intensity ratio (SPIR) from 1D H-2/H-1 NMR spectra for rapid distinction between natural and synthetic nicotine and detection of possible adulteration".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 411.24(2019):6427-6434.

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