Application of Metabolomics in the Study of Natural Products.

KIB OpenIR

	Application of Metabolomics in the Study of Natural Products.
	Zhao, Qi; Zhang, Jia-Le; Li, Fei
	2018
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	8 期号:4 页码:321-334
摘要	LC-MS-based metabolomics could have a major impact in the study of natural products, especially in its metabolism, toxicity and activity. This review highlights recent applications of metabolomics approach in the study of metabolites and toxicity of natural products, and the understanding of their effects on various diseases. Metabolomics has been employed to study the in vitro and in vivo metabolism of natural compounds, such as osthole, dehydrodiisoeugenol, and myrislignan. The pharmacological effects of natural compounds and extracts were determined using metabolomics technology combined with diseases models in animal, including osthole and nutmeg extracts. It has been demonstrated that metabolomics is a powerful technology for the investigation of xenobiotics-induced toxicity. The metabolism of triptolide and its hepatotoxicity were discussed. LC-MS-based metabolomics has a great potential in the druggability of natural products. The application of metabolomics should be broadened in the field of natural products in the future.
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64804
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhao, Qi,Zhang, Jia-Le,Li, Fei. Application of Metabolomics in the Study of Natural Products.[J]. Natural products and bioprospecting,2018,8(4):321-334.
APA	Zhao, Qi,Zhang, Jia-Le,&Li, Fei.(2018).Application of Metabolomics in the Study of Natural Products..Natural products and bioprospecting,8(4),321-334.
MLA	Zhao, Qi,et al."Application of Metabolomics in the Study of Natural Products.".Natural products and bioprospecting 8.4(2018):321-334.