Small-Molecule Targets in Tumor Immunotherapy.

KIB OpenIR

	Small-Molecule Targets in Tumor Immunotherapy.
	Zhu, Hui-Fang; Li, Yan
	2018
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	8 期号:4 页码:297-301
摘要	Cancer immunotherapy has been widely recognized as a powerful approach to fight cancers. To date, over 50 phase III trials in cancer immunotherapy are in progress. Among the many immunotherapy approaches, immune checkpoint therapy has attracted considerable attention. The reported clinical success of targeting the T cell immune checkpoint receptors PD-1 or CTLA4 by antibodies blockade in advanced stages of cancers has demonstrated the importance of immune modulation. But antibodies-based immunotherapy confronted with some disadvantages, such as immunogenicity, stability, membrane permeability, and production cost. Therefore, alternative approaches including small-molecule-regulated immune response are being introduced. In this review, we focused on some of the key intracellular pathways where small-molecule therapeutic is potential and attractive, which highlights the great potential of natural products in this field.
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64803
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Zhu, Hui-Fang,Li, Yan. Small-Molecule Targets in Tumor Immunotherapy.[J]. Natural products and bioprospecting,2018,8(4):297-301.
APA	Zhu, Hui-Fang,&Li, Yan.(2018).Small-Molecule Targets in Tumor Immunotherapy..Natural products and bioprospecting,8(4),297-301.
MLA	Zhu, Hui-Fang,et al."Small-Molecule Targets in Tumor Immunotherapy.".Natural products and bioprospecting 8.4(2018):297-301.