KIB OpenIR
Small-Molecule Targets in Tumor Immunotherapy.
Zhu, Hui-Fang; Li, Yan
2018
Source PublicationNatural products and bioprospecting
ISSN2192-2195
Volume8Issue:4Pages:297-301
AbstractCancer immunotherapy has been widely recognized as a powerful approach to fight cancers. To date, over 50 phase III trials in cancer immunotherapy are in progress. Among the many immunotherapy approaches, immune checkpoint therapy has attracted considerable attention. The reported clinical success of targeting the T cell immune checkpoint receptors PD-1 or CTLA4 by antibodies blockade in advanced stages of cancers has demonstrated the importance of immune modulation. But antibodies-based immunotherapy confronted with some disadvantages, such as immunogenicity, stability, membrane permeability, and production cost. Therefore, alternative approaches including small-molecule-regulated immune response are being introduced. In this review, we focused on some of the key intracellular pathways where small-molecule therapeutic is potential and attractive, which highlights the great potential of natural products in this field.
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64803
Collection中国科学院昆明植物研究所
Recommended Citation
GB/T 7714
Zhu, Hui-Fang,Li, Yan. Small-Molecule Targets in Tumor Immunotherapy.[J]. Natural products and bioprospecting,2018,8(4):297-301.
APA Zhu, Hui-Fang,&Li, Yan.(2018).Small-Molecule Targets in Tumor Immunotherapy..Natural products and bioprospecting,8(4),297-301.
MLA Zhu, Hui-Fang,et al."Small-Molecule Targets in Tumor Immunotherapy.".Natural products and bioprospecting 8.4(2018):297-301.
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