Matricellular Proteins Play a Potential Role in Acute Primary Angle Closure

KIB OpenIR

	Matricellular Proteins Play a Potential Role in Acute Primary Angle Closure
	Wang, Jing; Fu, Mingshui; Liu, Kun; Wang, Ning; Zhang, Zhihua; Zhou, Minwen; Xu, Xun
	2018
发表期刊	CURRENT EYE RESEARCH
ISSN	0271-3683
卷号	43 期号:6 页码:771-777
摘要	Purpose: To quantify levels of matricellular proteins in aqueous humor samples from acute primary angle closure (APAC) and non-glaucomatous cataract eyes and investigate their correlation with intraocular pressure (IOP) fluctuation.Materials and Methods: Aqueous humor samples were collected from 63 eyes including 29 current APAC eyes, 12 previous APAC eyes, and 22 cataract eyes. Concentrations of four main matricellular proteins (SPARC, tenascin-C, thrombospondin-2, and osteopontin) were measured using multiplexed immunoassay kits. Correlations between matricellular proteins and age, sex, and IOP were then detected using Spearman's rank correlation coefficient.Results: The levels of SPARC, thrombospondin-2, and osteopontin were significantly elevated in the APAC group as compared to the cataract group (p<0.001, p<0.001, and p=0.009, respectively). Further separation of the APAC group into current and previous APAC groups showed that only the differences of SPARC and thrombospondin-2 between the current APAC and cataract groups were significant (both p<0.001). All four matricellular proteins were found to have a positive correlation with IOP in the current APAC group but no correlation was found in the previous APAC or cataract groups.Conclusions: The levels of matricellular proteins were significantly elevated in the current APAC eyes and positively correlated to IOP. Further studies are necessary to investigate the molecular mechanisms and histological evidence of pathogenesis in matricellular proteins in APAC.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/64762
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang, Jing,Fu, Mingshui,Liu, Kun,et al. Matricellular Proteins Play a Potential Role in Acute Primary Angle Closure[J]. CURRENT EYE RESEARCH,2018,43(6):771-777.
APA	Wang, Jing.,Fu, Mingshui.,Liu, Kun.,Wang, Ning.,Zhang, Zhihua.,...&Xu, Xun.(2018).Matricellular Proteins Play a Potential Role in Acute Primary Angle Closure.CURRENT EYE RESEARCH,43(6),771-777.
MLA	Wang, Jing,et al."Matricellular Proteins Play a Potential Role in Acute Primary Angle Closure".CURRENT EYE RESEARCH 43.6(2018):771-777.