KIB OpenIR
Anticancer efficiency of cycloartane triterpenoid derivatives isolated from Cimicifuga yunnanensis Hsiao on triple-negative breast cancer cells
Li, Xiao; Wang, Wei; Fan, Yi; Wei, Yue; Yu, Li-Qin; Wei, Ji-Fu; Wang, Yi-Fen
2018
发表期刊CANCER MANAGEMENT AND RESEARCH
ISSN1179-1322
卷号10页码:6715-6729
摘要Background: The roots and rhizomes of Cimicifuga yunnanensis Hsiao are commonly used as anti-inflammatory, antipyretic, and analgesic remedies and detoxification agents in traditional Chinese medicine (TCM). Although C. yunnanensis has been considered as supplementary medicine for several disorders, the antitumor effect of this herb and its key components has not been explored. Materials and methods: The rhizomes of C. yunnanensis were isolated by chromatographic techniques. Structures of isolated compounds were identified based on spectroscopic methods and comparison with published data. The in vitro anticancer activities of purified components were also performed by MTT experiments. The in vivo anticancer activities were examined by subcutaneous tumor model or a breast cancer liver metastasis model. Results: In this study, we aimed to identify and characterize the effective antitumor components from the rhizomes of C. yunnanensis. By bioassay-guided fractionation techniques and chemical characterization, 12 cycloartane triterpenes and four chromones were isolated, among them, 11 compounds were identified in this genus at first. The identified two compounds showed dramatic inhibitory activities against breast cancer cells: compound 4 (23-epi-26-deoxyactein) and compound 13 (cimigenol). Then, we examined the antitumor effect of these two selective candidate chemicals on triple-negative breast cancer (TNBC) cells in vivo and found that they could reduce tumor growth in subcutaneous tumor model or breast cancer liver metastasis model. Conclusion: These results suggested that the selective compounds isolated from C. yunnanensis Hsiao could be the promising new agents for TNBC treatment.
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/64756
专题中国科学院昆明植物研究所
推荐引用方式
GB/T 7714
Li, Xiao,Wang, Wei,Fan, Yi,et al. Anticancer efficiency of cycloartane triterpenoid derivatives isolated from Cimicifuga yunnanensis Hsiao on triple-negative breast cancer cells[J]. CANCER MANAGEMENT AND RESEARCH,2018,10:6715-6729.
APA Li, Xiao.,Wang, Wei.,Fan, Yi.,Wei, Yue.,Yu, Li-Qin.,...&Wang, Yi-Fen.(2018).Anticancer efficiency of cycloartane triterpenoid derivatives isolated from Cimicifuga yunnanensis Hsiao on triple-negative breast cancer cells.CANCER MANAGEMENT AND RESEARCH,10,6715-6729.
MLA Li, Xiao,et al."Anticancer efficiency of cycloartane triterpenoid derivatives isolated from Cimicifuga yunnanensis Hsiao on triple-negative breast cancer cells".CANCER MANAGEMENT AND RESEARCH 10(2018):6715-6729.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Xiao]的文章
[Wang, Wei]的文章
[Fan, Yi]的文章
百度学术
百度学术中相似的文章
[Li, Xiao]的文章
[Wang, Wei]的文章
[Fan, Yi]的文章
必应学术
必应学术中相似的文章
[Li, Xiao]的文章
[Wang, Wei]的文章
[Fan, Yi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。