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Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp TJ507A
Xie, Shuangshuang; Wu, Ye; Qiao, Yuben; Guo, Yi; Wang, Jianping; Hu, Zhengxi; Zhang, Qing; Li, Xiaonian; Huang, Jinfeng; Zhou, Qun; Luo, Zengwei; Liu, Junjun; Zhu, Hucheng; Xue, Yongbo; Zhang, Yonghui
2018
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume81Issue:6Pages:1311-1320
AbstractTo explore the chemical diversity of metabolites from endophytic fungi, the strain Phomopsis sp. TJ507A, isolated from the medicinal plant Phyllanthus glaucus, was investigated. A 2,3-seco-protoilludane-type sesquiterpenoid (1), eight protoilludane-type sesquiterpenoids (2-9), four illudalane-type sesquiterpenoids (10a/10b, 11, and 12), and a botryane-type sesquiterpenoid (13) in addition to seven known sesquiterpenoids (14-20) were identified from the liquid culture of the fungus. Structures of the isolated compounds, including their absolute configurations, were elucidated based on extensive spectroscopic analyses, a modified Mosher analysis, electronic circular dichroism (ECD) calculations, and [Rh-2(OCOCF3)(4)]-induced ECD spectra as well as X-ray crystallographic analyses. Compound 1 represents the first example of a naturally occurring sesquiterpenoid containing the unusual 2,3-seco-protoilludane scaffold. Compounds 1 (p < 0.001); 2-6, 15, and 18 (p < 0.01); and 7, 9, and 20 (p < 0.05) displayed beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitory activities ranging from 19.4% to 43.8% at the concentration of 40 mu M. LY2811376 was used as the positive control with an inhibitory activity of 38.6% (p < 0.01). Furthermore, none of these compounds showed obvious hepatotoxicity at concentration of 40 mu M.
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64737
Collection中国科学院昆明植物研究所
Recommended Citation
GB/T 7714
Xie, Shuangshuang,Wu, Ye,Qiao, Yuben,et al. Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp TJ507A[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(6):1311-1320.
APA Xie, Shuangshuang.,Wu, Ye.,Qiao, Yuben.,Guo, Yi.,Wang, Jianping.,...&Zhang, Yonghui.(2018).Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp TJ507A.JOURNAL OF NATURAL PRODUCTS,81(6),1311-1320.
MLA Xie, Shuangshuang,et al."Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp TJ507A".JOURNAL OF NATURAL PRODUCTS 81.6(2018):1311-1320.
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