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Aspirin Derivative 5-(Bis(3-methylbut-2-enyl)amino)-2-hydroxybenzoic Acid Improves Thermotolerance via Stress Response Proteins in Caenorhabditis elegans
Huang, Xiao-Bing; Wu, Gui-Sheng; Ke, Lei-Yu; Zhou, Xiao-Gang; Wang, Yue-Hu; Luo, Huai-Rong
2018
Source PublicationMOLECULES
ISSN1420-3049
Volume23Issue:6Pages:1359
AbstractAging is a major risk factor for many prevalent diseases. Pharmacological intervention to improve the health span and extend the lifespan could be a preventive elixir for aging and age-related diseases. The non-steroid anti-inflammation medicine aspirin was reported to delay aging in Caenorhabditis elegans (C. elegans) and mice. We are wondering if the analogues of aspirin could also present antiaging activity. Here, we synthesized several aspirin derivatives and investigated their thermotolerance and antiaging effect in C. elegans. One of the compounds, 5-(bis(3-methylbut-2-en-1-yl)amino)-2-hydroxybenzoic acid, moderately increased the survival of C. elegans under heat stress, but could not extend the lifespan under optimum conditions. This compound could increase the mRNA level of stress response gene gst-4, and the mRNA and protein expression level of heat shock protein hsp-16.2 under heat stress. The failure of activating the transcription factor DAF-16 might explain why this compound could not act as aspirin to extend the lifespan of C. elegans. Our results would help further the investigation of the pharmacological activity of aspirin analogues and the relationship between structures and activity.
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/64735
Collection中国科学院昆明植物研究所
Recommended Citation
GB/T 7714
Huang, Xiao-Bing,Wu, Gui-Sheng,Ke, Lei-Yu,et al. Aspirin Derivative 5-(Bis(3-methylbut-2-enyl)amino)-2-hydroxybenzoic Acid Improves Thermotolerance via Stress Response Proteins in Caenorhabditis elegans[J]. MOLECULES,2018,23(6):1359.
APA Huang, Xiao-Bing,Wu, Gui-Sheng,Ke, Lei-Yu,Zhou, Xiao-Gang,Wang, Yue-Hu,&Luo, Huai-Rong.(2018).Aspirin Derivative 5-(Bis(3-methylbut-2-enyl)amino)-2-hydroxybenzoic Acid Improves Thermotolerance via Stress Response Proteins in Caenorhabditis elegans.MOLECULES,23(6),1359.
MLA Huang, Xiao-Bing,et al."Aspirin Derivative 5-(Bis(3-methylbut-2-enyl)amino)-2-hydroxybenzoic Acid Improves Thermotolerance via Stress Response Proteins in Caenorhabditis elegans".MOLECULES 23.6(2018):1359.
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