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Anti-inflammatory abietanes diterpenoids isolated from Tripterygium hypoglaucum
Chen, Xing-Long; Liu, Fang; Xiao, Xue-Rong; Yang, Xiu-Wei; Li, Fei
2018
发表期刊PHYTOCHEMISTRY
ISSN0031-9422
卷号156页码:167-175
摘要Tripterygium hypoglaucum (H. Lev.) Hutch. has been used to remedy rheumatoid arthritis, however, it shows frequent toxicity to the body. In this study, liquid chromatograph-mass spectrometer (LC-MS) was guided to characterize abietanes diterpenoids with anti-inflammatory activity from the stem of T. hypoglaucum. Thirteen undescribed abietanes diterpenoids were isolated and purified, and their chemical structure was identified using various spectroscopic methods. These compounds belonged to abietanes with splitting C ring, abietanes with benzenoid rings, diterpene quinoids, diterpene quinoids with lactone rings, and abietanes with benzenoid and lactone rings, respectively. Lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages was used to evaluate anti-inflammatory activity of the compounds. The results indicated that hypoglicin B-G and hypoglicin J-M exhibited inhibitory activity of NO production with the IC50 values of 6.01, 25.21, 8.29, 3.63, 0.72, 0.89, 36.91, 0.82, 2.85, 11.92 mu M, respectively. Among these compounds, compound hypoglicin L showed high anti-inflammatory activity and low toxicity (SI = 5.02 x 10(4)). Further QPCR analysis revealed that hypoglicin D and hypoglicin L can inhibit the mRNA expression of iNOS in LPS-stimulated RAW264.7 cells at doses of 12.5 and 3.13 mu M, respectively. Taken together, ten anti-inflammatory diterpenoids were found from T. hypoglaucum in this study.
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/64673
专题中国科学院昆明植物研究所
推荐引用方式
GB/T 7714
Chen, Xing-Long,Liu, Fang,Xiao, Xue-Rong,et al. Anti-inflammatory abietanes diterpenoids isolated from Tripterygium hypoglaucum[J]. PHYTOCHEMISTRY,2018,156:167-175.
APA Chen, Xing-Long,Liu, Fang,Xiao, Xue-Rong,Yang, Xiu-Wei,&Li, Fei.(2018).Anti-inflammatory abietanes diterpenoids isolated from Tripterygium hypoglaucum.PHYTOCHEMISTRY,156,167-175.
MLA Chen, Xing-Long,et al."Anti-inflammatory abietanes diterpenoids isolated from Tripterygium hypoglaucum".PHYTOCHEMISTRY 156(2018):167-175.
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