Knowledge Management System of Kunming Institute of Botany,CAS
Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense | |
Huang, Guang-Hui1; Hu, Zhu1; Lei, Chun1; Wang, Pei-Pei2; Yang, Jing3; Li, Jing-Ya2; Li, Jia2; Hou, Ai-Jun1 | |
2018-08-01 | |
发表期刊 | JOURNAL OF NATURAL PRODUCTS |
ISSN | 0163-3864 |
卷号 | 81期号:8页码:1810-1818 |
摘要 | Eight enantiomeric pairs of new meromono-terpenoids (1a/1b-8a/8b) and four known compounds (9-12) were isolated from Rhododendron nyingchiense. Their structures were established by spectroscopic methods, quantum chemical calculations, and X-ray crystallography. The enantiomeric pairs were acquired from scalemic mixtures by chiral-phase HPLC and showed diverse heterocyclic frameworks. Compounds 1a/1b possess a rare 6/7/5/5 heterocyclic system, and 2a/2b incorporate a new 6/6/3/5 heterocyclic system featuring a quinone motif. Compounds 3a/3b represent the first meroterpenoids with a 6/6/5 ring system from the Rhododendron genus. Putative biosynthetic pathways of these compounds are proposed. Compounds 1b, 2a-4a, 8a, and 11 exhibited weak inhibitory effects on PTP1B, with IC50 values ranging from 5.7 +/- 0.5 to 61.0 +/- 4.8 mu M. |
DOI | 10.1021/acs.jnatprod.8b00273 |
语种 | 英语 |
WOS记录号 | WOS:000443103700014 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.kib.ac.cn/handle/151853/62055 |
专题 | 中国科学院昆明植物研究所 |
通讯作者 | Hou, Ai-Jun |
作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmacognosy, State Key Lab Med Neurobiol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Medica, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Huang, Guang-Hui,Hu, Zhu,Lei, Chun,et al. Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense[J]. JOURNAL OF NATURAL PRODUCTS,2018,81(8):1810-1818. |
APA | Huang, Guang-Hui.,Hu, Zhu.,Lei, Chun.,Wang, Pei-Pei.,Yang, Jing.,...&Hou, Ai-Jun.(2018).Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense.JOURNAL OF NATURAL PRODUCTS,81(8),1810-1818. |
MLA | Huang, Guang-Hui,et al."Enantiomeric Pairs of Meroterpenoids with Diverse Heterocyclic Systems from Rhododendron nyingchiense".JOURNAL OF NATURAL PRODUCTS 81.8(2018):1810-1818. |
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