Hypofolins A - L, ent-Labdane Diterpenoids from the Roots of Hypoestes phyllostachya "Pink Splash'
Cheng, Bin1,2,3; Ding, Lin-Fen2,3; Yan, Tong1,2,3; Xie, Zhang-Qiao1,2,3; Zhang, Zhi-jun1; Song, Liu-Dong2,3; Wu, Xing-De1; Zhao, Qin-Shi1
2018-06-01
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号15期号:6
摘要Twelve new ent-labdane diterpenoids, hypofolins A - F (1 - 6) and hypofolins G - L (7a/7b, 8a/8b, and 9a/9b), were isolated from the roots of Hypoestes phyllostachya Pink Splash'. Their structures were elucidated by extensive 1D- and 2D-NMR spectroscopic and HR-MS data. The absolute configurations of 1, 2, 5, and 7a/7b were determined by single crystal X-ray diffraction and ECD analysis, as well as chemical transformations. Compounds 7a/7b, 8a/8b, and 9a/9b were isolated as three pairs of interconverting mixture of two isomers between ketone and hemiketal types. Compound 1 showed weak cytotoxicity against SMMC-7721 cell line with IC50 value of 31.40 m.
关键词Hypoestes Phyllostachya Ent-labdane Diterpenoids Hypofolins a - l Cytotoxicity No Production Inhibitory Activity
语种英语
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/61377
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China
3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China
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Cheng, Bin,Ding, Lin-Fen,Yan, Tong,et al. Hypofolins A - L, ent-Labdane Diterpenoids from the Roots of Hypoestes phyllostachya "Pink Splash'[J]. CHEMISTRY & BIODIVERSITY,2018,15(6).
APA Cheng, Bin.,Ding, Lin-Fen.,Yan, Tong.,Xie, Zhang-Qiao.,Zhang, Zhi-jun.,...&Zhao, Qin-Shi.(2018).Hypofolins A - L, ent-Labdane Diterpenoids from the Roots of Hypoestes phyllostachya "Pink Splash'.CHEMISTRY & BIODIVERSITY,15(6).
MLA Cheng, Bin,et al."Hypofolins A - L, ent-Labdane Diterpenoids from the Roots of Hypoestes phyllostachya "Pink Splash'".CHEMISTRY & BIODIVERSITY 15.6(2018).
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