Botanical origin and chemical constituents of commercial Saposhnikoviae radix and its related crude drugs available in Shaanxi and the surrounding regions
Maruyama, Takuro1; Ezaki, Masami2; Shiba, Mao3; Yamaji, Hiroki3; Yoshitomi, Taichi1; Kawano, Noriaki2; Zhu, Shu4; Cheng, Xiao5; Yokokura, Tsuguo6; Yamamoto, Yutaka7; Fuchino, Hiroyuki2; Sun, Hang5; Komatsu, Katsuko4; Kawahara, Nobuo2
2018
Source PublicationJOURNAL OF NATURAL MEDICINES
ISSN1340-3443
Volume72Issue:1Pages:267-273
Abstract

Saposhnikoviae radix (SR) is described in the Japanese Pharmacopoeia as a crude drug derived from the root of Saposhnikovia divaricata Schischkin (Umbelliferae). According to Flora of China, the root of Peucedanum ledebourielloides K. F. Fu is used as a regional substitute for SR. Therefore, we surveyed the botanical origin of the drug used in China, especially Shaanxi and the surrounding regions, through nucleotide sequence analysis of the internal transcribed spacer region of rDNA. As a result, several samples from Shaanxi (..) and Shanxi (..) provinces were identified as Peucedanum ledebourielloides. To prevent this substitute from being distributed as genuine SR, we developed a thin- layer chromatography analysis condition to enable a specific compound of this species to be easily detected. The specific compound was identified as xanthalin, based on 1D- and 2D- NMR and high- resolution mass spectrometry data. The established TLC conditions were as followsextraction solvent, n- hexane; applied volume, 5 mu L; chromatographic support, silica gel; developing solvent, n- hexane: ethyl acetate: acetic acid (20: 10: 1); developing length, 7 cm; detection, UV (365 nm); Rf value, 0.4 (blue fluorescence; xanthalin).

KeywordSaposhnikoviae Radix Shaanxi Province Peucedanum Ledebourielloides Tlc Xanthalin
DOI10.1007/s11418-017-1149-7
Language英语
WOS IDWOS:000423036900031
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/60590
Collection中国科学院东亚植物多样性与生物地理学重点实验室
Affiliation1.Natl Inst Hlth Sci, Div Pharmacognosy Phytochem & Narcot, Kawasaki Ku, 3-25-26 Tonomachi, Kawasaki, Kanagawa 2109501, Japan
2.Natl Inst Biomed Innovat Hlth & Nutr, Res Ctr Med Plant Resources, 1-2 Hachimandai, Tsukuba, Ibaraki 3050843, Japan
3.Tsumura & Co, Bot Raw Mat Res Labs, 3586 Yoshiwara, Ami, Ibaraki 3001192, Japan
4.Univ Toyama, Inst Nat Med, Div Pharmacognosy, Dept Med Resources, 2630 Sugitani, Toyama 9300194, Japan
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
6.Nippon Funmatsu Yakuhin Co Ltd, Chuo Ku, 2-5-11 Doshomachi, Osaka 5410045, Japan
7.Tochimoto Tenkaido Co Ltd, Tamba, Hyogo 6693315, Japan
Recommended Citation
GB/T 7714
Maruyama, Takuro,Ezaki, Masami,Shiba, Mao,et al. Botanical origin and chemical constituents of commercial Saposhnikoviae radix and its related crude drugs available in Shaanxi and the surrounding regions[J]. JOURNAL OF NATURAL MEDICINES,2018,72(1):267-273.
APA Maruyama, Takuro.,Ezaki, Masami.,Shiba, Mao.,Yamaji, Hiroki.,Yoshitomi, Taichi.,...&Kawahara, Nobuo.(2018).Botanical origin and chemical constituents of commercial Saposhnikoviae radix and its related crude drugs available in Shaanxi and the surrounding regions.JOURNAL OF NATURAL MEDICINES,72(1),267-273.
MLA Maruyama, Takuro,et al."Botanical origin and chemical constituents of commercial Saposhnikoviae radix and its related crude drugs available in Shaanxi and the surrounding regions".JOURNAL OF NATURAL MEDICINES 72.1(2018):267-273.
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