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题名: In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae)
作者: Xiang, Yangfei2; Pei, Ying2; Qu, Chang2; Lai, Zhicai2; Ren, Zhe2; Yang, Ke2; Xiong, Sheng2; null(张颖君)3; Yang, Chongren3; Wang, Dong3; Liu, Qing3; Kitazato, Kaio4; Wang, Yifei1, 2
刊名: PHYTOTHERAPY RESEARCH
关键词: anti-herpes simplex virus activity ; HSV ; 1,2,4,6-tetra-O-galloyl-beta-D-glucose ; polyphenol ; Phyllanthus emblica L. (Euphorbiaceae)
英文摘要: In this study, 1,2,4,6-tetra-O-galloyl-beta-D-glucose (1246TGG), a polyphenolic compound isolated from traditional Chinese medicine Phyllanthus emblica L. (Euphorbiaceae), was found to inhibit herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infection at different magnitudes of activity in vitro. Further studies revealed that 1246TGG directly inactivated HSV-1 particles, leading to the failure of early infection, including viral attachment and penetration. 1246TGG also suppressed the intracellular growth of HSV-1 within a long period post-infection (from 0 h p.i. to 12 h p.i.), while it might exert an antiviral effect mainly before 3 h p.i. It inhibited HSV-1 E and L gene expressions as well as viral DNA replication but did not affect the RNA synthesis of IE gene in our study. Also, in the presence of 1246TGG, the synthesis of viral protein was reduced. Taken together, it was suggested that 1246TGG might exert anti-HSV activity both by inactivating extracellular viral particles and by inhibiting viral biosynthesis in host cells. These results warrant further studies on the antiviral mechanisms of 1246TGG and suggest that it might be a candidate for HSV therapy. Copyright (C) 2011 John Wiley & Sons, Ltd.
出版日期: 2011-07-01
卷号: 25, 期号:7, 页码:975-982
DOI标识: 10.1002/ptr.3368
语种: 英语
ISSN号: 0951-418X
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/3956
Appears in Collections:中国科学院东亚植物多样性与生物地理学重点实验室_期刊论文

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作者单位: 1.Jinan Univ, Biomed Res & Dev Ctr, Guangdong Prov Key Lab Bioengn Med, Guangzhou 510632, Guangdong, Peoples R China
2.Jinan Univ, Natl Engn Res Ctr Genet Med, Guangzhou 510632, Guangdong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China
4.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Lab Mol Biol Infect Agents, Nagasaki 852, Japan

Recommended Citation:
Xiang, Yangfei; Pei, Ying; Qu, Chang; Lai, Zhicai; Ren, Zhe; Yang, Ke; Xiong, Sheng; Zhang, Yingjun; Yang, Chongren; Wang, Dong; Liu, Qing; Kitazato, Kaio; Wang, Yifei.In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae),PHYTOTHERAPY RESEARCH,2011,25(7):975-982
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