In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae)
Xiang, Yangfei2; Pei, Ying2; Qu, Chang2; Lai, Zhicai2; Ren, Zhe2; Yang, Ke2; Xiong, Sheng2; Zhang, Yingjun3; Yang, Chongren3; Wang, Dong3; Liu, Qing3; Kitazato, Kaio4; Wang, Yifei1,2
2011-07-01
发表期刊PHYTOTHERAPY RESEARCH
ISSN0951-418X
卷号25期号:7页码:975-982
摘要In this study, 1,2,4,6-tetra-O-galloyl-beta-D-glucose (1246TGG), a polyphenolic compound isolated from traditional Chinese medicine Phyllanthus emblica L. (Euphorbiaceae), was found to inhibit herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infection at different magnitudes of activity in vitro. Further studies revealed that 1246TGG directly inactivated HSV-1 particles, leading to the failure of early infection, including viral attachment and penetration. 1246TGG also suppressed the intracellular growth of HSV-1 within a long period post-infection (from 0 h p.i. to 12 h p.i.), while it might exert an antiviral effect mainly before 3 h p.i. It inhibited HSV-1 E and L gene expressions as well as viral DNA replication but did not affect the RNA synthesis of IE gene in our study. Also, in the presence of 1246TGG, the synthesis of viral protein was reduced. Taken together, it was suggested that 1246TGG might exert anti-HSV activity both by inactivating extracellular viral particles and by inhibiting viral biosynthesis in host cells. These results warrant further studies on the antiviral mechanisms of 1246TGG and suggest that it might be a candidate for HSV therapy. Copyright (C) 2011 John Wiley & Sons, Ltd.
关键词Anti-herpes Simplex Virus Activity Hsv Polyphenol 1 PhyL.anthus EmbL.ca L. (Euphorbiaceae) 2 4 6-tetra-o-galloyl-beta-d-glucose
资助信息National Science Foundation of China[U0632010]; State Key Laboratory of Phytochemistry and Plant Resources in West China, Chinese Academy of Sciences[P2008-KF07, P2008-ZZ08]; MOE[211]
学科领域Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1002/ptr.3368
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000293031400004
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/3956
专题中国科学院东亚植物多样性与生物地理学重点实验室
作者单位1.Jinan Univ, Biomed Res & Dev Ctr, Guangdong Prov Key Lab Bioengn Med, Guangzhou 510632, Guangdong, Peoples R China
2.Jinan Univ, Natl Engn Res Ctr Genet Med, Guangzhou 510632, Guangdong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China
4.Nagasaki Univ, Grad Sch Biomed Sci, Dept Mol Microbiol & Immunol, Lab Mol Biol Infect Agents, Nagasaki 852, Japan
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Xiang, Yangfei,Pei, Ying,Qu, Chang,et al. In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae)[J]. PHYTOTHERAPY RESEARCH,2011,25(7):975-982.
APA Xiang, Yangfei.,Pei, Ying.,Qu, Chang.,Lai, Zhicai.,Ren, Zhe.,...&Wang, Yifei.(2011).In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae).PHYTOTHERAPY RESEARCH,25(7),975-982.
MLA Xiang, Yangfei,et al."In vitro Anti-Herpes Simplex Virus Activity of 1,2,4,6-Tetra-O-galloyl-beta-D-glucose from Phyllanthus emblica L. (Euphorbiaceae)".PHYTOTHERAPY RESEARCH 25.7(2011):975-982.
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