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New lignans with neuroprotective activity from Adelostemma gracillimum
Zhang, Jun1,2,5; Guo, Shengjun1,2; Chan, Kim W.1,2; Tong, Estella P. S.1,2; Fu, Guangmiao1,2; Mu, Quanzhang3; Ip, Fanny C. F.1,2,4; Ip, Nancy Y.1,2,4
2016-06-01
发表期刊PHYTOCHEMISTRY LETTERS
卷号16页码:1-7
摘要Adelostemma gracillimum is an herb used as nourishing and roborant drugs and in the treatment of convulsions in children. To date, a few molecular constituents have been isolated from the root of this herb and chemically characterized, but their biological activities have never been reported. Here, we demonstrate that the crude extract of A. gracillimum (AGE) can protect primary cortical neurons against N-methyl-D-aspartate (NMDA)-induced cytotoxicity. Further fractionations of AGE led to the isolation of four novel lignans (1-4), two known lignans (5,11), and five known acetophenones (6-10); their structures were elucidated by comparison with related literature, extensive analyses of NMR spectroscopy and high-resolution mass spectrometry. Of the eleven isolates, lignans 2, 3 and 5 exhibit significant neuroprotection against NMDA-induced cell death. This is the first report of isolating lignans with neuroprotective activity from A. gracillimum. (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
关键词Adelostemma Gracillimum Cortical Neurons Nmda Excitotoxicity Lignans Neolignans Acetophenones
资助信息Hong Kong Research Grants Council Theme-based Research Scheme(T13-607/12R); National Key Basic Research Program of China(2013CB530900); Innovation and Technology Fund for State Key Laboratory(ITCPT/17-9); Shenzhen Peacock Plan; SH Ho Foundation
DOI10.1016/j.phytol.2016.02.011
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000378027300001
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文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/26284
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作者单位1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
2.Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Hong Kong, Hong Kong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China
4.HKUST Shenzhen Res Inst, Guangdong Key Lab Brain Sci Dis & Drug Dev, Shenzhen, Guangdong, Peoples R China
5.Jinan Univ, Coll Sci & Technol, Guangzhou, Guangdong, Peoples R China
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GB/T 7714
Zhang, Jun,Guo, Shengjun,Chan, Kim W.,et al. New lignans with neuroprotective activity from Adelostemma gracillimum[J]. PHYTOCHEMISTRY LETTERS,2016,16:1-7.
APA Zhang, Jun.,Guo, Shengjun.,Chan, Kim W..,Tong, Estella P. S..,Fu, Guangmiao.,...&Ip, Nancy Y..(2016).New lignans with neuroprotective activity from Adelostemma gracillimum.PHYTOCHEMISTRY LETTERS,16,1-7.
MLA Zhang, Jun,et al."New lignans with neuroprotective activity from Adelostemma gracillimum".PHYTOCHEMISTRY LETTERS 16(2016):1-7.
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