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题名: New lignans with neuroprotective activity from Adelostemma gracillimum
作者: Zhang, Jun1, 2, 5; Guo, Shengjun1, 2; Chan, Kim W.1, 2; Tong, Estella P. S.1, 2; Fu, Guangmiao1, 2; Mu, Quanzhang3; Ip, Fanny C. F.1, 2, 4; Ip, Nancy Y.1, 2, 4
刊名: PHYTOCHEMISTRY LETTERS
关键词: Adelostemma gracillimum ; Cortical neurons ; NMDA excitotoxicity ; Lignans ; Neolignans ; Acetophenones
英文摘要: Adelostemma gracillimum is an herb used as nourishing and roborant drugs and in the treatment of convulsions in children. To date, a few molecular constituents have been isolated from the root of this herb and chemically characterized, but their biological activities have never been reported. Here, we demonstrate that the crude extract of A. gracillimum (AGE) can protect primary cortical neurons against N-methyl-D-aspartate (NMDA)-induced cytotoxicity. Further fractionations of AGE led to the isolation of four novel lignans (1-4), two known lignans (5,11), and five known acetophenones (6-10); their structures were elucidated by comparison with related literature, extensive analyses of NMR spectroscopy and high-resolution mass spectrometry. Of the eleven isolates, lignans 2, 3 and 5 exhibit significant neuroprotection against NMDA-induced cell death. This is the first report of isolating lignans with neuroprotective activity from A. gracillimum. (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
出版日期: 2016-06-01
卷号: 16, 页码:1-7
DOI标识: 10.1016/j.phytol.2016.02.011
语种: 英语
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/26284
Appears in Collections:离退休_期刊论文

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作者单位: 1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
2.Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Hong Kong, Hong Kong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China
4.HKUST Shenzhen Res Inst, Guangdong Key Lab Brain Sci Dis & Drug Dev, Shenzhen, Guangdong, Peoples R China
5.Jinan Univ, Coll Sci & Technol, Guangzhou, Guangdong, Peoples R China
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