New lignans with neuroprotective activity from Adelostemma gracillimum

doi:10.1016/j.phytol.2016.02.011

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	New lignans with neuroprotective activity from Adelostemma gracillimum
	Zhang, Jun 1,2,5; Guo, Shengjun 1,2; Chan, Kim W.1,2; Tong, Estella P. S.1,2; Fu, Guangmiao 1,2; Mu, Quanzhang 3; Ip, Fanny C. F.1,2,4; Ip, Nancy Y.1,2,4
	2016-06-01
发表期刊	PHYTOCHEMISTRY LETTERS
卷号	16 页码:1-7
摘要	Adelostemma gracillimum is an herb used as nourishing and roborant drugs and in the treatment of convulsions in children. To date, a few molecular constituents have been isolated from the root of this herb and chemically characterized, but their biological activities have never been reported. Here, we demonstrate that the crude extract of A. gracillimum (AGE) can protect primary cortical neurons against N-methyl-D-aspartate (NMDA)-induced cytotoxicity. Further fractionations of AGE led to the isolation of four novel lignans (1-4), two known lignans (5,11), and five known acetophenones (6-10); their structures were elucidated by comparison with related literature, extensive analyses of NMR spectroscopy and high-resolution mass spectrometry. Of the eleven isolates, lignans 2, 3 and 5 exhibit significant neuroprotection against NMDA-induced cell death. This is the first report of isolating lignans with neuroprotective activity from A. gracillimum. (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
关键词	Adelostemma Gracillimum Cortical Neurons Nmda Excitotoxicity Lignans Neolignans Acetophenones
DOI	10.1016/j.phytol.2016.02.011
收录类别	SCI
语种	英语
WOS记录号	WOS:000378027300001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/26284
专题	离退休
作者单位	1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China 2.Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Hong Kong, Hong Kong, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China 4.HKUST Shenzhen Res Inst, Guangdong Key Lab Brain Sci Dis & Drug Dev, Shenzhen, Guangdong, Peoples R China 5.Jinan Univ, Coll Sci & Technol, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jun,Guo, Shengjun,Chan, Kim W.,et al. New lignans with neuroprotective activity from Adelostemma gracillimum[J]. PHYTOCHEMISTRY LETTERS,2016,16:1-7.
APA	Zhang, Jun.,Guo, Shengjun.,Chan, Kim W..,Tong, Estella P. S..,Fu, Guangmiao.,...&Ip, Nancy Y..(2016).New lignans with neuroprotective activity from Adelostemma gracillimum.PHYTOCHEMISTRY LETTERS,16,1-7.
MLA	Zhang, Jun,et al."New lignans with neuroprotective activity from Adelostemma gracillimum".PHYTOCHEMISTRY LETTERS 16(2016):1-7.

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