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New lignans with neuroprotective activity from Adelostemma gracillimum
Zhang, Jun1,2,5; Guo, Shengjun1,2; Chan, Kim W.1,2; Tong, Estella P. S.1,2; Fu, Guangmiao1,2; Mu, Quanzhang3; Ip, Fanny C. F.1,2,4; Ip, Nancy Y.1,2,4
2016-06-01
Source PublicationPHYTOCHEMISTRY LETTERS
Volume16Pages:1-7
AbstractAdelostemma gracillimum is an herb used as nourishing and roborant drugs and in the treatment of convulsions in children. To date, a few molecular constituents have been isolated from the root of this herb and chemically characterized, but their biological activities have never been reported. Here, we demonstrate that the crude extract of A. gracillimum (AGE) can protect primary cortical neurons against N-methyl-D-aspartate (NMDA)-induced cytotoxicity. Further fractionations of AGE led to the isolation of four novel lignans (1-4), two known lignans (5,11), and five known acetophenones (6-10); their structures were elucidated by comparison with related literature, extensive analyses of NMR spectroscopy and high-resolution mass spectrometry. Of the eleven isolates, lignans 2, 3 and 5 exhibit significant neuroprotection against NMDA-induced cell death. This is the first report of isolating lignans with neuroprotective activity from A. gracillimum. (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
KeywordAdelostemma Gracillimum Cortical Neurons Nmda Excitotoxicity Lignans Neolignans Acetophenones
DOI10.1016/j.phytol.2016.02.011
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS SubjectBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000378027300001
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/26284
Collection离退休
Affiliation1.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
2.Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Hong Kong, Hong Kong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming, Peoples R China
4.HKUST Shenzhen Res Inst, Guangdong Key Lab Brain Sci Dis & Drug Dev, Shenzhen, Guangdong, Peoples R China
5.Jinan Univ, Coll Sci & Technol, Guangzhou, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jun,Guo, Shengjun,Chan, Kim W.,et al. New lignans with neuroprotective activity from Adelostemma gracillimum[J]. PHYTOCHEMISTRY LETTERS,2016,16:1-7.
APA Zhang, Jun.,Guo, Shengjun.,Chan, Kim W..,Tong, Estella P. S..,Fu, Guangmiao.,...&Ip, Nancy Y..(2016).New lignans with neuroprotective activity from Adelostemma gracillimum.PHYTOCHEMISTRY LETTERS,16,1-7.
MLA Zhang, Jun,et al."New lignans with neuroprotective activity from Adelostemma gracillimum".PHYTOCHEMISTRY LETTERS 16(2016):1-7.
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