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Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities
Li, Xiao-Li1; Li, Yang1,2; Wang, Si-Feng3; Zhao, Yan-Li1,2; Liu, Ke-Chun3; Wang, Xi-Min3; Yang, Yong-Ping1,4
2009-06-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume72Issue:6Pages:1001-1005
AbstractTen new ingol lathyrane-type diterpenes (1-10) and two known ingenol derivatives (11 and 12) were isolated from the aerial parts of Euphorbia royleana. The structures of 1-10 were elucidated on the basis of spectroscopic methods including 2D NMR analysis, and the structure of compound I was confirmed by single-crystal X-ray crystallography. Antiangiogenic effects of all compounds except for 5 were tested using a zebrafish model, with compounds 11 and 12 being active in this bioassay.; Ten new ingol lathyrane-type diterpenes (1-10) and two known ingenol derivatives (11 and 12) were isolated from the aerial parts of Euphorbia royleana. The structures of 1-10 were elucidated on the basis of spectroscopic methods including 2D NMR analysis, and the structure of compound I was confirmed by single-crystal X-ray crystallography. Antiangiogenic effects of all compounds except for 5 were tested using a zebrafish model, with compounds 11 and 12 being active in this bioassay.
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np800816n
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000267432600004
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/2623
Collection中国科学院青藏高原研究所昆明部
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, Lab Ethnobot, Kunming Yunnan 650204, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiao-Li,Li, Yang,Wang, Si-Feng,et al. Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(6):1001-1005.
APA Li, Xiao-Li.,Li, Yang.,Wang, Si-Feng.,Zhao, Yan-Li.,Liu, Ke-Chun.,...&Yang, Yong-Ping.(2009).Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities.JOURNAL OF NATURAL PRODUCTS,72(6),1001-1005.
MLA Li, Xiao-Li,et al."Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities".JOURNAL OF NATURAL PRODUCTS 72.6(2009):1001-1005.
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