Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities

doi:10.1021/np800816n

	Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities
	Li, Xiao-Li 1; Li, Yang 1,2; Wang, Si-Feng 3; Zhao, Yan-Li 1,2; Liu, Ke-Chun 3; Wang, Xi-Min 3; Yang, Yong-Ping1,4
	2009-06-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	72 期号:6 页码:1001-1005
摘要	Ten new ingol lathyrane-type diterpenes (1-10) and two known ingenol derivatives (11 and 12) were isolated from the aerial parts of Euphorbia royleana. The structures of 1-10 were elucidated on the basis of spectroscopic methods including 2D NMR analysis, and the structure of compound I was confirmed by single-crystal X-ray crystallography. Antiangiogenic effects of all compounds except for 5 were tested using a zebrafish model, with compounds 11 and 12 being active in this bioassay.; Ten new ingol lathyrane-type diterpenes (1-10) and two known ingenol derivatives (11 and 12) were isolated from the aerial parts of Euphorbia royleana. The structures of 1-10 were elucidated on the basis of spectroscopic methods including 2D NMR analysis, and the structure of compound I was confirmed by single-crystal X-ray crystallography. Antiangiogenic effects of all compounds except for 5 were tested using a zebrafish model, with compounds 11 and 12 being active in this bioassay.
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np800816n
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000267432600004
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2623
专题	中国科学院青藏高原研究所昆明部
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Lab Ethnobot, Kunming Yunnan 650204, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China 3.Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiao-Li,Li, Yang,Wang, Si-Feng,et al. Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(6):1001-1005.
APA	Li, Xiao-Li.,Li, Yang.,Wang, Si-Feng.,Zhao, Yan-Li.,Liu, Ke-Chun.,...&Yang, Yong-Ping.(2009).Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities.JOURNAL OF NATURAL PRODUCTS,72(6),1001-1005.
MLA	Li, Xiao-Li,et al."Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities".JOURNAL OF NATURAL PRODUCTS 72.6(2009):1001-1005.

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