Six new C-21 steroidal glycosides from Asclepias curassavica L.
Li, JZ ; Liu, HY ; Lin, YJ ; Hao, XJ ; Ni, W ; Chen, CX
2008
发表期刊STEROIDS
ISSN0039-128X
卷号73期号:6页码:594-600
摘要Six new C-21 steroidal glycosides, named curassavosides A-F (3-8), were obtained from the aerial parts of Asclepias curassavica (Asclepiadaceae), along with two known oxypregnanes, 12-O-benzoyldeacylmetaplexigenin (1) and 12-O-benzoylsarcostin (2). By spectroscopic methods, the structures of the six new compounds were determined as 12-O-benzoyldeacylmetaplexigenin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (3), 12-O-benzoylsarcostin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (4), sarcostin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (5), sarcostin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-digitoxopyranoside (6), 12-O-benzoyldeacylmetaplexigenin 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyrano side (7), and 12-O-benzoylsarcostin 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-oleandropyranosyl(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (8), respectively. All compounds (1-8) were tested for in vitro cytotoxicity; only compound 3 showed weak inhibitory activity against Raji and AGZY cell lines. (C) 2008 Elsevier Inc. All rights reserved.
关键词Asclepias Curassavica Asclepiadaceae C-21 Steroidal Glycosides
学科领域Biochemistry & Molecular Biology ; Endocrinology & Metabolism
收录类别sci
语种英语
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1849
专题植物化学与西部植物资源持续利用国家重点实验室
推荐引用方式
GB/T 7714
Li, JZ,Liu, HY,Lin, YJ,et al. Six new C-21 steroidal glycosides from Asclepias curassavica L.[J]. STEROIDS,2008,73(6):594-600.
APA Li, JZ,Liu, HY,Lin, YJ,Hao, XJ,Ni, W,&Chen, CX.(2008).Six new C-21 steroidal glycosides from Asclepias curassavica L..STEROIDS,73(6),594-600.
MLA Li, JZ,et al."Six new C-21 steroidal glycosides from Asclepias curassavica L.".STEROIDS 73.6(2008):594-600.
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