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题名: Six new C-21 steroidal glycosides from Asclepias curassavica L.
作者: Li, JZ ; null(刘海洋) ; Lin, YJ ; null(郝小江) ; Ni, W ; Chen, CX
刊名: STEROIDS
关键词: Asclepias curassavica ; Asclepiadaceae ; C-21 steroidal glycosides
英文摘要: Six new C-21 steroidal glycosides, named curassavosides A-F (3-8), were obtained from the aerial parts of Asclepias curassavica (Asclepiadaceae), along with two known oxypregnanes, 12-O-benzoyldeacylmetaplexigenin (1) and 12-O-benzoylsarcostin (2). By spectroscopic methods, the structures of the six new compounds were determined as 12-O-benzoyldeacylmetaplexigenin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (3), 12-O-benzoylsarcostin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (4), sarcostin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (5), sarcostin 3-O-beta-D-oleandropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-digitoxopyranoside (6), 12-O-benzoyldeacylmetaplexigenin 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyrano side (7), and 12-O-benzoylsarcostin 3-O-beta-D-glucopyranosyl-(1-->4)-beta-D-oleandropyranosyl(1-->4)-beta-D-canaropyranosyl-(1-->4)-beta-D-oleandropyranosyl-(1-->4)-beta-D-digitoxopyranoside (8), respectively. All compounds (1-8) were tested for in vitro cytotoxicity; only compound 3 showed weak inhibitory activity against Raji and AGZY cell lines. (C) 2008 Elsevier Inc. All rights reserved.
出版日期: 2008
卷号: 73, 期号:6, 页码:594-600
语种: 英语
收录类别: sci
学科分类: Biochemistry & Molecular Biology; Endocrinology & Metabolism
ISSN号: 0039-128X
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/1849
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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Recommended Citation:
Li, JZ; Liu, HY; Lin, YJ; Hao, XJ; Ni, W; Chen, CX.Six new C-21 steroidal glycosides from Asclepias curassavica L.,STEROIDS,2008,73(6):594-600
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