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题名: Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp YXf3
作者: Guo, Zhi Kai1; Wang, Rong2; Huang, Wei3; Li, Xiao Nian4; Jiang, Rong3; Tan, Ren Xiang3; Ge, Hui Ming3
刊名: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
出版日期: 2014-11-17
卷号: 10, 期号:8, 页码:2677-2682
关键词: Aspergillus ; endophytic fungus ; Ginkgo biloba ; natural product ; norditerpenoid ; Trichocomaceae
学科分类: Chemistry, Organic
DOI: 10.3762/bjoc.10.282
通讯作者: Tan,RX (reprint author),Nanjing Univ,Inst Funct Biomol,State Key Lab Pharmaceut Biotechnol,Nanjing 210093,Jiangsu,Peoples R China. ; rxtan@nju.edu.cn ; hmge@nju.edu.cn
文章类型: Article
英文摘要: An unusual C-18 norditerpenoid, aspergiloid I (1), was isolated from the culture broth of Aspergillus sp. YXf3, an endophytic fungus derived from Ginkgo biloba. Its structure was unambiguously established by analysis of HRMS-ESI and spectroscopic data, and the absolute configuration was determined by low-temperature (100 K) single crystal X-ray diffraction with Cu K alpha radiation. This compound is structurally characterized by a new carbon skeleton with an unprecedented 6/5/6 tricyclic ring system bearing an alpha,beta-unsaturated spirolactone moiety in ring B, and represents a new subclass of norditerpenoid, the skeleton of which is named aspergilane. The hypothetical biosynthetic pathway for 1 was also proposed. The cytotoxic, antimicrobial, anti-oxidant and enzyme inhibitory activities of 1 were evaluated.
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: PIMARANE DITERPENES ; METABOLITES ; ALKALOIDS ; CUPRESSI
收录类别: SCI
项目资助者: National Natural Science Foundation of China [30900075]
语种: 英语
WOS记录号: WOS:000345172700001
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18473
Appears in Collections:植物化学与西部植物资源持续利用国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China
2.Hainan Acad Ocean & Fisheries Sci, Haikou 570203, Hainan, Peoples R China
3.Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China
4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

Recommended Citation:
Guo,Zhi Kai;Wang,Rong;Huang,Wei;Li,Xiao Nian;Jiang,Rong;Tan,Ren Xiang;Ge,Hui Ming.Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp YXf3,BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2014,114(8):1701-1709
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文件名: Guo-2014-Aspergiloid I, an unprecedented spiro.pdf
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