Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx
Wang, Wei-Guang1,2; Li, Xiao-Nian1; Du, Xue1; Wu, Hai-Yan1; Liu, Xu1; Su, Jia1; Li, Yan1; Pu, Jian-Xin1; Sun, Han-Dong1
2012-06-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号75期号:6页码:1102-1107
摘要Laxiflorolides A (1) and B (2), two unprecedented epimeric bishomoditerpene lactones with a unique C-22 framework, along with laxiflorins P-R (3-5), maoecrystal P (6), maoecrystal C (7), and eriocalyxin B (8), were isolated from the leaves of I. eriocalyx var. laxiflora. The structures of 1 and 2, including the absolute configurations, were determined by spectroscopic methods and single-crystal X-ray diffraction analysis. All of the compounds isolated were evaluated for their cytotoxicity against five tumor cell lines. Compounds 3, 6, and 8 showed remarkable cytotoxic activity against certain cell lines compared with the positive control.
关键词Ent-kaurane Diterpenoids Var. Laxiflora Leukemic-cells Cytotoxicity Induction Differentiation Antioxidant Macrophages Products Pharicin
资助信息The authors are grateful to Prof. X.-W. Li of the Kunming Institute of Botany, Chinese Academy of Sciences, for the identification of the plant. This project was supported financially by the NSFC-Joint Foundation of Yunnan Province (No. U0832602 to H.-D.S.), the National Natural Science Foundation of China (No. 81172939 to J.-X.P.), the Major State Basic Research Development Program of China (No. 2009CB522300), the Reservation-Talent Project of Yunnan Province (2011CI043 to J.-X.P.), the Science and Technology Program of Yunnan Province (No. 2008IF010), and the Major Direction Projection Foundation of CAS intellectual Innovation Project (No. KSCX2-EW-J-24 to J.-X.P.).
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np300106j
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000305503500014
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17607
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Wang, Wei-Guang,Li, Xiao-Nian,Du, Xue,et al. Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(6):1102-1107.
APA Wang, Wei-Guang.,Li, Xiao-Nian.,Du, Xue.,Wu, Hai-Yan.,Liu, Xu.,...&Sun, Han-Dong.(2012).Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx.JOURNAL OF NATURAL PRODUCTS,75(6),1102-1107.
MLA Wang, Wei-Guang,et al."Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx".JOURNAL OF NATURAL PRODUCTS 75.6(2012):1102-1107.
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