7,8-Secolignans from Schisandra wilsoniana and Their Anti-HIV-1 Activities
Zhang, Xing-Jie2,3; Yang, Guang-Yu1; Wang, Rui-Rui1; Pu, Jian-Xin1; Sun, Han-Dong1; Xiao, Wei-Lie1; Zheng, Yong-Tang2
2010
发表期刊CHEMISTRY & BIODIVERSITY
ISSN1612-1872
卷号7期号:11页码:2692-2701
摘要Two new 7,8-secolignans, marphenols A and B (1 and 2, resp.), together with a known related derivative, 7,8-secoholostylone B (3). were isolated from the stems of Schisandra wilsoniana. The structures of 1 and 2 were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. The anti-HIV-1 activities of 1-3 were evaluated. Compound 1 inhibited HIV-1(IIIB)-induced syncytia formation with an EC(50) value of 0.55 mu g ml(-1). It reduced p24 antigen expression in acutely HIV-1-(IIIB)-infected C8166 cells and primary isolate HIV-1(Tc-2)-infected peripheral blood mononuclear cells (PBMCs), with EC(50) values of 3.34 and 0.52 mu g ml(-1), respectively. It showed no effects on the HIV-1(IIIB) replication in chronically infected H9 cells as well as fusion inhibition.
资助信息NSFC [30830115, 20802082]; Chinese Academy of Sciences [KSCX1-YW-R-24, KSCX2-YW-R-185]; 973 Program [2009CB522300, 2009CB940900]; Scientific and Technological projects of China [2008ZX10001-015, 2009ZX09501-029, 2008ZX10005-005]; 863 Program [2006AA020602]; Young Academic and Technical Leader Rising Foundation of Yunnan Province [2006PY01-47]
学科领域Multidisciplinary ; Biochemistry & Molecular Biology ; Chemistry
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000284967200003
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/1509
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
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Zhang, Xing-Jie,Yang, Guang-Yu,Wang, Rui-Rui,et al. 7,8-Secolignans from Schisandra wilsoniana and Their Anti-HIV-1 Activities[J]. CHEMISTRY & BIODIVERSITY,2010,7(11):2692-2701.
APA Zhang, Xing-Jie.,Yang, Guang-Yu.,Wang, Rui-Rui.,Pu, Jian-Xin.,Sun, Han-Dong.,...&Zheng, Yong-Tang.(2010).7,8-Secolignans from Schisandra wilsoniana and Their Anti-HIV-1 Activities.CHEMISTRY & BIODIVERSITY,7(11),2692-2701.
MLA Zhang, Xing-Jie,et al."7,8-Secolignans from Schisandra wilsoniana and Their Anti-HIV-1 Activities".CHEMISTRY & BIODIVERSITY 7.11(2010):2692-2701.
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