7,8-Secolignans from Schisandra wilsoniana and Their Anti-HIV-1 Activities
Zhang, Xing-Jie2,3; Yang, Guang-Yu1; Wang, Rui-Rui1; Pu, Jian-Xin1; Sun, Han-Dong1; Xiao, Wei-Lie1; Zheng, Yong-Tang2
AbstractTwo new 7,8-secolignans, marphenols A and B (1 and 2, resp.), together with a known related derivative, 7,8-secoholostylone B (3). were isolated from the stems of Schisandra wilsoniana. The structures of 1 and 2 were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. The anti-HIV-1 activities of 1-3 were evaluated. Compound 1 inhibited HIV-1(IIIB)-induced syncytia formation with an EC(50) value of 0.55 mu g ml(-1). It reduced p24 antigen expression in acutely HIV-1-(IIIB)-infected C8166 cells and primary isolate HIV-1(Tc-2)-infected peripheral blood mononuclear cells (PBMCs), with EC(50) values of 3.34 and 0.52 mu g ml(-1), respectively. It showed no effects on the HIV-1(IIIB) replication in chronically infected H9 cells as well as fusion inhibition.
Subject AreaMultidisciplinary ; Biochemistry & Molecular Biology ; Chemistry
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000284967200003
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Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xing-Jie,Yang, Guang-Yu,Wang, Rui-Rui,et al. 7,8-Secolignans from Schisandra wilsoniana and Their Anti-HIV-1 Activities[J]. CHEMISTRY & BIODIVERSITY,2010,7(11):2692-2701.
APA Zhang, Xing-Jie.,Yang, Guang-Yu.,Wang, Rui-Rui.,Pu, Jian-Xin.,Sun, Han-Dong.,...&Zheng, Yong-Tang.(2010).7,8-Secolignans from Schisandra wilsoniana and Their Anti-HIV-1 Activities.CHEMISTRY & BIODIVERSITY,7(11),2692-2701.
MLA Zhang, Xing-Jie,et al."7,8-Secolignans from Schisandra wilsoniana and Their Anti-HIV-1 Activities".CHEMISTRY & BIODIVERSITY 7.11(2010):2692-2701.
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